Embryotoxicity of regressing corpora lutea in ewes

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Lipid metabolism in regressing rat corpora lutea of pregnancy.

Lipid accumulation is a hallmark of corpus luteum regression and we characterized lipids stored in rat corpora lutea of pregnancy between days 21 and 24 post coitum, the period of luteolysis. A 10-fold rise in lutein triglyceride concentrations occurred between days 21 and 24, which represented the major alteration in luteal lipid metabolism during luteolysis, coinciding with the appearance of ...

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Exogenous estradiol enhances apoptosis in regressing post-partum rat corpora lutea possibly mediated by prolactin

BACKGROUND In pregnant rats, structural luteal regression takes place after parturition and is associated with cell death by apoptosis. We have recently shown that the hormonal environment is responsible for the fate of the corpora lutea (CL). Changing the levels of circulating hormones in post-partum rats, either by injecting androgen, progesterone, or by allowing dams to suckle, was coupled w...

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Formation and function of GnRH-induced subnormal corpora lutea in cyclic ewes.

Of 19 dioestrous ewes given 50 micrograms GnRH on Day 10 of the oestrous cycle, 15 (79%) formed corpora haemorrhagica within 2 days after injection of GnRH. After excision of the Day 10 spontaneous CL, the GnRH-induced CL were short lived when compared to spontaneous CL in saline-treated ewes (3.1 +/- 0.4 vs 17.3 +/- 0.3 days, respectively). Hysterectomy of ewes bearing the GnRH-induced CL prev...

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PGF2 alpha-induced milk ejection in ewes having cyclic or pregnant corpora lutea.

The production of luteal oxytocin in ewes, resulting from the intrajugular injection of 200 micrograms of PGF2 alpha, could be determined by the increase in intramammary pressure. This simple indirect method of measuring the activity of the corpus luteum enabled easy detection of renewed post-partum ovulation or the onset of pregnancy. The response was monitored every two days between Days 0 an...

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Role of the uterus in early regression of corpora lutea induced by the ram effect in seasonally anoestrous Barbarine ewes.

The involvement of the uterus in early regression of corpora lutea induced by the ram effect was studied in seasonally anoestrous Barbarine ewes. In experiment 1, group I was only submitted to the male effect (control, n = 15) while group II (n = 14) was injected every 12 h with flunixin meglumine, a PGF2 alpha synthetase inhibitor (finadyne), from day 3 to day 6 (day 0: day of ram introduction...

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ژورنال

عنوان ژورنال: Reproduction

سال: 2001

ISSN: 1470-1626,1741-7899

DOI: 10.1530/rep.0.1220883